Sources and Suggestions for Further Inquiry

Victoria Berdon

This resource for The Least of My Brothers lists other materials you might like to examine to further your understanding of the medical and ethical aspects of the PHS Syphilis Study at Tuskegee, as well as the social, cultural, and historical setting. Included are links to other websites, titles of books, historical documents (and links to them, where possible), news media, and other useful reference materials. Close this window when you are ready to return to the scenario.


Sources of Primary Value | Other Sources of Historical Documents | Other Interesting Sources


Sources of Primary Value

Other Sources of Historical Documents

Other Interesting Sources

Sex Education and Syphilis: Information and Attitudes 1829 – 1924

Other Interesting Sources

Neurosyphilis Studies Prior to the PHS Syphilis Study at Tuskegee

Other Interesting Sources

Syphilis Studies Begun after the Start of the 1930 Demonstration of Its Prevalence

Other Interesting Sources

13 Articles Generated by the Researchers Doing the Study

In chronological order:

1936 Vonderlehr, R.A. et al. "Untreated Syphilis in the Male Negro: A Comparative Study of Treated and Untreated Cases." Venereal Disease Information 17 (1936), 260-65.
1946 Heller, J.R. et al. "Untreated Syphilis in the Male Negro: II. Mortality During 12 Years of Observation." Venereal Disease Information 27(1946), 34-38.
1946 Deibert, A.V. et al. "Untreated Syphilis in the Male Negro: III. Evidence of Cardiovascular Abnormalities Over Sixteen Years." Journal of Venereal Disease Information 27 (1946), 301-314.
1950 Pesare, Pasquale J. et al. "Untreated Syphilis in the Male Negro: Observation of Abnormalities Over Sixteen Years." American Journal of Syphilis, Gonorrhea, and Venereal Diseases 34 (1950), 201-213.
1953 Rivers, Eunice et al. "Twenty Years of Follow-Up Experience in a Long-Range Medical Study." Public Health Reports 68 (1953), 391-95.
1954 Shafer, J.K. et al. "Untreated Syphilis in the Male Negro: A Prospective Study of the Effect on Life Expectancy." Public Health Reports 69 (1954) and Milbank Fund Memorial Quarterly 32 (1954), 261-74.
1954 Olansky, Sydney et al. "Environmental Factors in the Tuskegee Study of Untreated Syphilis." Public Health Reports 69 (1954), 691-98.
1955 Peters, Jesse J. et al. "Untreated Syphilis in the Male Negro: Pathologic Findings in Syphilitic and Nonsyphilitic Patients." Journal of Chronic Diseases 1 (1955), 127-48.
1955 Schuman, Stanley H. et al. "Untreated Syphilis in the Male Negro: Background and Current Status of Patients in the Tuskegee Study." Journal of Chronic Diseases 2 (1955), 543-58.
1956 Olansky, Sydney et al. "Untreated Syphilis in the Male Negro: X. Twenty Years of Clinical Observation of Untreated Syphilitic and Presumably Nonsyphilitic Groups." Journal of Chronic Diseases 4 (1956), 177-85.
1956 Olansky, Sydney et al. "Untreated Syphilis in the Male Negro: Twenty-two Years of Serologic Observation in a Selected Syphilis Study Group." AMA Archives of Dermatology 73 (1956), 516-22.
1961 Rockwell, Donald H. et al. "The Tuskegee Study of Untreated Syphilis: The 30th Year of Observation." Archives of Internal Medicine 114 (1961), 792-98.
1973 Caldwell, Joseph G. et al. "Aortic Regurgitation in the Tuskegee Study of Untreated Syphilis." Journal of Chronic Diseases 26 (1973), 187-94.

Other Interesting Sources

Nurse Eunice Rivers

Dibble and Smith’s articles discuss the complexity in trying to assess Nurse Rivers’ role as the primary liaison between the subjects and the doctors performing the study.

Other Interesting Sources

Reaction to the Study After It Became Public

Reactions extend far beyond the study itself and currently effect other major public health issues such as with AIDS education, prevention, and treatment.

In chronological order:

1966 Buxtun, Peter. Letter from Peter Buxtun to Dr. William Brown, Director of the Division of Venereal Diseases, November 6, 1966. Tuskegee Files, Center for Disease Control. [Note: This is the original letter in which Buxtun expresses moral concerns about the study.]
1972 Kampmeier, R.H. "The Tuskegee Study of Untreated Syphilis." Southern Medical Journal 65:10 (Oct. 1972), 1247-51.
1973 United States. Tuskegee Syphilis Study Ad Hoc Advisory Panel: Final Report. Washington, D.C.: U.S. Public Health Service, 1973.
1973 "The Tuskegee Study." Journal of the Oklahoma State Medical Association 66:2 (Feb. 1973), 47-51.
1973 "Treponemes and Tuskegee." Lancet 1:7817 (23 Jun. 1973), 1438.
1973 Cobb, W.M. "The Tuskegee Syphilis Study." Journal of the National Medical Association 65:4 (Jul. 1973), 345-48.
1973 Curran, W.J. "The Tuskegee Syphilis Study." New England Journal of Medicine 289:14 (4 Oct. 1973), 730-31.
1974 MacDonald, C.J. "Communications: The contribution of the Tuskegee study to medical knowledge." Journal of the National Medical Association 6:1 (Jan. 1974), 1-7.
1974 Kampmeier R.H. "Final report on the 'Tuskegee Syphilis Study.'" Southern Medical Journal 67:11 (Nov. 1974), 1349-53.
1981 Jones, James H. Bad Blood: the Tuskegee Syphilis Experiment. New York: Macmillan, 1993, c1981. [Note: This is the single most-cited book on the study. It presents an excellent history, with extensive documentation and bibliography. If you read only one thing, read this. This book also contains a chapter on the effects of the study on attitudes of American blacks toward the public health system today, especially with regard to AIDS.]
1996 Roy, B. "The Julius Rosenwald Fund syphilis seroprevalence studies." Journal of the National Medical Association 88:5 (May 1996), 315-22.
2000 Thomas, Stephen B. and Quinn, Sandra Crouse. "The Tuskegee Syphilis Study 1932-1972: Implications for HIV Education and AIDS Risk Education Programs in the Black Community." Reverby, Susan M. ed. Tuskegee ’s Truths: Rethinking the Tuskegee Syphilis Study. Chapel Hill: University of North Carolina Press, 2000.

Other Interesting Sources

Effects of the Study on Research Ethics after 1972

In chronological order:

1975 Cave, V.G. "Proper uses and abuses of the health care delivery system for minorities with special reference to the Tuskegee syphilis study." Journal of the National Medical Association 67:1 (Jan. 1975), 82-4.
1978 Benedek, T.G. "The ‘Tuskegee Study’ of syphilis: analysis of moral versus methodologic aspects." Journal of Chronic Diseases 31:1 (Jan. 1978), 35-50.
1978 Brandt, Allan. "Racism and Research: The Case of the Tuskegee Syphilis Study." Sickness and Health in America: Readings in the History of Medicine and Public Health. Edited by Judith Walzer Leavitt and Ronald L. Numbers. Madison: University of Wisconsin Press, 1985. 331-343. Originally published in Hastings Center Report 8:6 (Dec. 1978), 21-29. Also in Reverby, 2000.
1982 Rothman, D.J. "Were the Tuskegee and Willowbrook ‘studies in nature’?" Hastings Center Report 12:2 (Apr. 1982), 5-7.
1982 Savitt, Todd L. "The Use of Blacks for Medical Experimentation and Demonstration in the Old South," Journal of Southern History 48 (Aug. 1982), 331-48.
1982 Shick , Tom W. "Race, Class, and Medicine: ‘Bad Blood’ in Twentieth-Century America." Journal of Ethnic Studies 10 (Summer 1982), 97-105.
1985 Solomon, Martha. "The rhetoric of dehumanization: an analysis of medical reports of the Tuskegee syphilis project." Western Journal of Speech and Communication 49:4 (1985), 233-47.
1987 Brandt, Allan M. No Magic Bullet: A Social History of Venereal Disease in the U.S. since 1880. New York: Oxford University Press, 1987.
1988 Coney, Sandra and Bunkle, Phillida. "An Unfortunate Experiment at National Women’s," Monash Bioethics Review 8:1 (1988): 3-36. [Note: Notice the year – 1988 – and the similarity of the study reported herein to the PHS Syphilis Study at Tuskegee.]
1990 Yoon, Carol Kaesuk. "Families Emerge as Silent Victims of Tuskegee Syphilis Experiment" New York Times 146 (5 May 1990).
1991 Thomas S.B., Quinn, S.C. "The Tuskegee Syphilis Study, 1932 to 1972: implications for HIV education and AIDS risk education programs in the black community." American Journal of Public Health 81 (1991), 1498-1506.
1992 Annas, George J. and Grodin, Michael A., eds. The Nazi Doctors and the Nuremberg Code. New York: Oxford University Press, 1992.
1992 Caplan, Arthur L. "When Evil Intrudes." Hastings Center Report 22:6 (Nov./Dec. 1992), 29-32.
1992 Edgar, Harold. "Outside the Community." Hastings Center Report 22:6 (Nov./Dec. 1992), 32-35.
1992 J.D.W. "Race, genocide, and public health." American Journal of Medicine 92:3 (Mar. 1992).
1992 Jones, James. "The Tuskegee Legacy: AIDS and the Black Community." Hastings Center Report 22:6 (Nov./Dec. 1992), 38-40.
1992 King, Patricia A. "The Dangers of Difference." Hastings Center Report 22:6 (Nov./Dec. 1992), 35-38.
1993 Susceptible to Kindness: Miss Evers’ Boys and the Tuskegee Syphilis Study. Videorecording. Ithaca , NY: Cornell University, 1993. [Note: Includes, among other things, excerpts from David Feldshuh’s play Miss Evers’ Boys and comments by nurses, physicians, government officials, and James Jones (the author of Bad Blood.)]
1993 Junod, Tom. "Deadly Medicine." GQ: Gentlemen’s Quarterly 63:6 (Jun. 1993).
1993 Critical Thinking in Nursing: Lessons from Tuskegee. Videorecording. New York, NY: National League for Nursing Videos, 1993. [Note: This program investigates nurse Eunice Rivers’s involvement in the PHS Syphilis Study at Tuskegee and how it might be interpreted today.]
1993 The Deadly Deception. Videorecording. New York: Nova, WGBH Educational Foundation, 26 Jan. 1993. Produced and narrated by George Strait. [Note: See the review by Bryan and Peggy Bryers in Journal of Criminal Justice and Popular Culture, and review article "Practicing Bad Medicine" in Newsweek (1 Feb. 1993), 66.]
1994 Fourtner, A.W. et al. "Bad Blood: A case study of the Tuskegee syphilis project." Journal of College Science Teaching 23 (1994), 277-285.
1994 Solomon, Martha. "The rhetoric of dehumanization: an analysis of medical reports of the Tuskegee Syphilis Project." Critical Questions: Invention, Creativity, and the Criticism of Discourse and Media. Edited by William L. Nothstine, Carole Blair, Gary A. Copeland. New York: St. Martin’s Press, 1994.
1994 Washington, Harriet. "Human Guinea Pigs." Emerge 6:1 (Oct. 1994), 24.
1995 Roy, B. "The Tuskegee Syphilis Experiment: Biotechnology and the Administrative State." Journal of the National Medical Association 87:1 (Jan. 1995), 56-67.
1996 Smith, Susan L. "Neither Victim nor Villain: Nurse Eunice Rivers, the Tuskegee Syphilis Experiment, and Public Health Work." Journal of Women’s History 8:1 (Spr. 1996), 95-113.
1996 Venderpool, Harold Y. The Ethics of Research Involving Human Subjects: Facing the 21st Century. Frederick, MD: University Publishing Group, Frederick, 1996.
1996 Shelton, Deborah L. "The Legacy of Tuskegee." American Medical News 39:21 (3 Jun. 1996), 10-14.
1996 Coughlin, S.S. et al. "Remember Tuskegee: Public Health Student Knowledge of the Ethical Significance of the Tuskegee Syphilis Study." American Journal of Preventive Medicine 12:4 (Jul./Aug. 1996), 242-46.
1996 Pace, Brian P. and Sullivan-Fowler, Micaela. "Proposed Compensation for Tuskegee Study Men." Journal of the American Medical Association 276:20 (27 Nov. 1996), 1692.
1997 Gamble, Vanessa. "Under the shadow of Tuskegee: African Americans and health care." American Journal of Public Health 87:11 (Nov. 1997), 1773-1778.
1997 Geiger, H. Jack. "Annotation: Racism resurgent – building a bridge to the 19th century." American Journal of Public Health 87:11 (Nov. 1997), 1765.
1997 Wolinsky, Howard. "Steps still being taken to undo damage of America ’s Nuremberg ." Annals of Internal Medicine 127:4 (15 Aug. 1997), 1-43.
1997 Ho, David and Wilfert, Catherine. "AIDS experts quit NEJM over editorial." Women’s Health Weekly (27 Oct. 1997), 2-3.
1997 Sargent, Joseph, dir. Miss Evers’ Boys. Videorecording. HBO Films, 1997. Based on the play by David Feldshuh.
1998 Gray, Fred. The Tuskegee Syphilis Study: The Real Story and Beyond. Montgomery, AL: Black Belt Press, 1998. [Note: Fred Gray is an attorney for some of the survivors.]
1998 Brawley, O.W. "The Study of Untreated Syphilis in the Negro Male." International Journal of Radiation Oncology and Biological Physics 40:1 (1 Jan. 1998), 5-8.
1999 Fairchild, Amy L. and Bayer, Ronald. "Uses and Abuses of Tuskegee." Science 284:5416 (7 May 1999), 919.
1999 Benedek, Thomas G. and Erlen, Jonathon. "The Scientific Environment of the Tuskegee Study of Syphilis, 1920-1960." Perspectives in Biology and Medicine 43:1 (Fall 1999), 1-30.
2000 Reverby, Susan, ed. Tuskegee’s Truths: Rethinking the Tuskegee Syphilis Study. Chapel Hill: University of North Carolina Press, 2000.
2000 White, Robert M. "Unraveling the Tuskegee Study of Untreated Syphilis." Archives of Internal Medicine 160:5 (2000), 585.

While the PHS Syphilis Study at Tuskegee may not be directly responsible for changes to international codes of medical ethics, especially regarding informed consent, it is useful to see the progress made in this area. See the Resource entitled Codes of Medical and Human Experimentation Ethics, especially:

1947 The Nuremberg Code: Provides standards to be followed by physicians experimenting on human subjects. For example, the person involved should have legal capacity to give consent, and the experiment should protect the experimental subject against even remote possibilities of injury, disability or death.
1948 Declaration of Geneva, Physician's Oath: (Revised in 1968, 1983, and 1994.) The physician pledges that the first commitment is to serve humanity, always putting the health of he patient first and will maintain the "utmost respect for human life."
1953 Wilson Memo: The subjects should be protected from harm as much as possible. If it looks like the experiment is doing more harm than good, the researcher must stop the experiment, no matter what stage it’s in.
2000 Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects: The focus of the Introduction is the primacy of patient health and well-being, with special attention to those "research populations are vulnerable and need special protection" as well as for "those who cannot give or refuse consent for themselves, for those who may be subject to giving consent under duress, for those who will not benefit personally from the research and for those for whom the research is combined with care."

Other Interesting Sources

President Clinton’s Apology

Other Interesting Sources

Other Items of Historical Interest

Other Interesting Sources


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