This resource for The Least of My Brothers lists other materials you might like to examine to further your understanding of the medical and ethical aspects of the PHS Syphilis Study at Tuskegee, as well as the social, cultural, and historical setting. Included are links to other websites, titles of books, historical documents (and links to them, where possible), news media, and other useful reference materials. Close this window when you are ready to return to the scenario.
In chronological order:
| 1936 | Vonderlehr, R.A. et al. "Untreated Syphilis in the Male Negro: A Comparative Study of Treated and Untreated Cases." Venereal Disease Information 17 (1936), 260-65. |
| 1946 | Heller, J.R. et al. "Untreated Syphilis in the Male Negro: II. Mortality During 12 Years of Observation." Venereal Disease Information 27(1946), 34-38. |
| 1946 | Deibert, A.V. et al. "Untreated Syphilis in the Male Negro: III. Evidence of Cardiovascular Abnormalities Over Sixteen Years." Journal of Venereal Disease Information 27 (1946), 301-314. |
| 1950 | Pesare, Pasquale J. et al. "Untreated Syphilis in the Male Negro: Observation of Abnormalities Over Sixteen Years." American Journal of Syphilis, Gonorrhea, and Venereal Diseases 34 (1950), 201-213. |
| 1953 | Rivers, Eunice et al. "Twenty Years of Follow-Up Experience in a Long-Range Medical Study." Public Health Reports 68 (1953), 391-95. |
| 1954 | Shafer, J.K. et al. "Untreated Syphilis in the Male Negro: A Prospective Study of the Effect on Life Expectancy." Public Health Reports 69 (1954) and Milbank Fund Memorial Quarterly 32 (1954), 261-74. |
| 1954 | Olansky, Sydney et al. "Environmental Factors in the Tuskegee Study of Untreated Syphilis." Public Health Reports 69 (1954), 691-98. |
| 1955 | Peters, Jesse J. et al. "Untreated Syphilis in the Male Negro: Pathologic Findings in Syphilitic and Nonsyphilitic Patients." Journal of Chronic Diseases 1 (1955), 127-48. |
| 1955 | Schuman, Stanley H. et al. "Untreated Syphilis in the Male Negro: Background and Current Status of Patients in the Tuskegee Study." Journal of Chronic Diseases 2 (1955), 543-58. |
| 1956 | Olansky, Sydney et al. "Untreated Syphilis in the Male Negro: X. Twenty Years of Clinical Observation of Untreated Syphilitic and Presumably Nonsyphilitic Groups." Journal of Chronic Diseases 4 (1956), 177-85. |
| 1956 | Olansky, Sydney et al. "Untreated Syphilis in the Male Negro: Twenty-two Years of Serologic Observation in a Selected Syphilis Study Group." AMA Archives of Dermatology 73 (1956), 516-22. |
| 1961 | Rockwell, Donald H. et al. "The Tuskegee Study of Untreated Syphilis: The 30th Year of Observation." Archives of Internal Medicine 114 (1961), 792-98. |
| 1973 | Caldwell, Joseph G. et al. "Aortic Regurgitation in the Tuskegee Study of Untreated Syphilis." Journal of Chronic Diseases 26 (1973), 187-94. |
Dibble and Smith’s articles discuss the complexity in trying to assess Nurse Rivers’ role as the primary liaison between the subjects and the doctors performing the study.
Reactions extend far beyond the study itself and currently effect other major public health issues such as with AIDS education, prevention, and treatment.
In chronological order:
| 1966 | Buxtun, Peter. Letter from Peter Buxtun to Dr. William Brown, Director of the Division of Venereal Diseases, November 6, 1966. Tuskegee Files, Center for Disease Control. [Note: This is the original letter in which Buxtun expresses moral concerns about the study.] |
| 1972 | Kampmeier, R.H. "The Tuskegee Study of Untreated Syphilis." Southern Medical Journal 65:10 (Oct. 1972), 1247-51. |
| 1973 | United States. Tuskegee Syphilis Study Ad Hoc Advisory Panel: Final Report. Washington, D.C.: U.S. Public Health Service, 1973. |
| 1973 | "The Tuskegee Study." Journal of the Oklahoma State Medical Association 66:2 (Feb. 1973), 47-51. |
| 1973 | "Treponemes and Tuskegee." Lancet 1:7817 (23 Jun. 1973), 1438. |
| 1973 | Cobb, W.M. "The Tuskegee Syphilis Study." Journal of the National Medical Association 65:4 (Jul. 1973), 345-48. |
| 1973 | Curran, W.J. "The Tuskegee Syphilis Study." New England Journal of Medicine 289:14 (4 Oct. 1973), 730-31. |
| 1974 | MacDonald, C.J. "Communications: The contribution of the Tuskegee study to medical knowledge." Journal of the National Medical Association 6:1 (Jan. 1974), 1-7. |
| 1974 | Kampmeier R.H. "Final report on the 'Tuskegee Syphilis Study.'" Southern Medical Journal 67:11 (Nov. 1974), 1349-53. |
| 1981 | Jones, James H. Bad Blood: the Tuskegee Syphilis Experiment. New York: Macmillan, 1993, c1981. [Note: This is the single most-cited book on the study. It presents an excellent history, with extensive documentation and bibliography. If you read only one thing, read this. This book also contains a chapter on the effects of the study on attitudes of American blacks toward the public health system today, especially with regard to AIDS.] |
| 1996 | Roy, B. "The Julius Rosenwald Fund syphilis seroprevalence studies." Journal of the National Medical Association 88:5 (May 1996), 315-22. |
| 2000 | Thomas, Stephen B. and Quinn, Sandra Crouse. "The Tuskegee Syphilis Study 1932-1972: Implications for HIV Education and AIDS Risk Education Programs in the Black Community." Reverby, Susan M. ed. Tuskegee ’s Truths: Rethinking the Tuskegee Syphilis Study. Chapel Hill: University of North Carolina Press, 2000. |
In chronological order:
| 1975 | Cave, V.G. "Proper uses and abuses of the health care delivery system for minorities with special reference to the Tuskegee syphilis study." Journal of the National Medical Association 67:1 (Jan. 1975), 82-4. |
| 1978 | Benedek, T.G. "The ‘Tuskegee Study’ of syphilis: analysis of moral versus methodologic aspects." Journal of Chronic Diseases 31:1 (Jan. 1978), 35-50. |
| 1978 | Brandt, Allan. "Racism and Research: The Case of the Tuskegee Syphilis Study." Sickness and Health in America: Readings in the History of Medicine and Public Health. Edited by Judith Walzer Leavitt and Ronald L. Numbers. Madison: University of Wisconsin Press, 1985. 331-343. Originally published in Hastings Center Report 8:6 (Dec. 1978), 21-29. Also in Reverby, 2000. |
| 1982 | Rothman, D.J. "Were the Tuskegee and Willowbrook ‘studies in nature’?" Hastings Center Report 12:2 (Apr. 1982), 5-7. |
| 1982 | Savitt, Todd L. "The Use of Blacks for Medical Experimentation and Demonstration in the Old South," Journal of Southern History 48 (Aug. 1982), 331-48. |
| 1982 | Shick , Tom W. "Race, Class, and Medicine: ‘Bad Blood’ in Twentieth-Century America." Journal of Ethnic Studies 10 (Summer 1982), 97-105. |
| 1985 | Solomon, Martha. "The rhetoric of dehumanization: an analysis of medical reports of the Tuskegee syphilis project." Western Journal of Speech and Communication 49:4 (1985), 233-47. |
| 1987 | Brandt, Allan M. No Magic Bullet: A Social History of Venereal Disease in the U.S. since 1880. New York: Oxford University Press, 1987. |
| 1988 | Coney, Sandra and Bunkle, Phillida. "An Unfortunate Experiment at National Women’s," Monash Bioethics Review 8:1 (1988): 3-36. [Note: Notice the year – 1988 – and the similarity of the study reported herein to the PHS Syphilis Study at Tuskegee.] |
| 1990 | Yoon, Carol Kaesuk. "Families Emerge as Silent Victims of Tuskegee Syphilis Experiment" New York Times 146 (5 May 1990). |
| 1991 | Thomas S.B., Quinn, S.C. "The Tuskegee Syphilis Study, 1932 to 1972: implications for HIV education and AIDS risk education programs in the black community." American Journal of Public Health 81 (1991), 1498-1506. |
| 1992 | Annas, George J. and Grodin, Michael A., eds. The Nazi Doctors and the Nuremberg Code. New York: Oxford University Press, 1992. |
| 1992 | Caplan, Arthur L. "When Evil Intrudes." Hastings Center Report 22:6 (Nov./Dec. 1992), 29-32. |
| 1992 | Edgar, Harold. "Outside the Community." Hastings Center Report 22:6 (Nov./Dec. 1992), 32-35. |
| 1992 | J.D.W. "Race, genocide, and public health." American Journal of Medicine 92:3 (Mar. 1992). |
| 1992 | Jones, James. "The Tuskegee Legacy: AIDS and the Black Community." Hastings Center Report 22:6 (Nov./Dec. 1992), 38-40. |
| 1992 | King, Patricia A. "The Dangers of Difference." Hastings Center Report 22:6 (Nov./Dec. 1992), 35-38. |
| 1993 | Susceptible to Kindness: Miss Evers’ Boys and the Tuskegee Syphilis Study. Videorecording. Ithaca , NY: Cornell University, 1993. [Note: Includes, among other things, excerpts from David Feldshuh’s play Miss Evers’ Boys and comments by nurses, physicians, government officials, and James Jones (the author of Bad Blood.)] |
| 1993 | Junod, Tom. "Deadly Medicine." GQ: Gentlemen’s Quarterly 63:6 (Jun. 1993). |
| 1993 | Critical Thinking in Nursing: Lessons from Tuskegee. Videorecording. New York, NY: National League for Nursing Videos, 1993. [Note: This program investigates nurse Eunice Rivers’s involvement in the PHS Syphilis Study at Tuskegee and how it might be interpreted today.] |
| 1993 | The Deadly Deception. Videorecording. New York: Nova, WGBH Educational Foundation, 26 Jan. 1993. Produced and narrated by George Strait. [Note: See the review by Bryan and Peggy Bryers in Journal of Criminal Justice and Popular Culture, and review article "Practicing Bad Medicine" in Newsweek (1 Feb. 1993), 66.] |
| 1994 | Fourtner, A.W. et al. "Bad Blood: A case study of the Tuskegee syphilis project." Journal of College Science Teaching 23 (1994), 277-285. |
| 1994 | Solomon, Martha. "The rhetoric of dehumanization: an analysis of medical reports of the Tuskegee Syphilis Project." Critical Questions: Invention, Creativity, and the Criticism of Discourse and Media. Edited by William L. Nothstine, Carole Blair, Gary A. Copeland. New York: St. Martin’s Press, 1994. |
| 1994 | Washington, Harriet. "Human Guinea Pigs." Emerge 6:1 (Oct. 1994), 24. |
| 1995 | Roy, B. "The Tuskegee Syphilis Experiment: Biotechnology and the Administrative State." Journal of the National Medical Association 87:1 (Jan. 1995), 56-67. |
| 1996 | Smith, Susan L. "Neither Victim nor Villain: Nurse Eunice Rivers, the Tuskegee Syphilis Experiment, and Public Health Work." Journal of Women’s History 8:1 (Spr. 1996), 95-113. |
| 1996 | Venderpool, Harold Y. The Ethics of Research Involving Human Subjects: Facing the 21st Century. Frederick, MD: University Publishing Group, Frederick, 1996. |
| 1996 | Shelton, Deborah L. "The Legacy of Tuskegee." American Medical News 39:21 (3 Jun. 1996), 10-14. |
| 1996 | Coughlin, S.S. et al. "Remember Tuskegee: Public Health Student Knowledge of the Ethical Significance of the Tuskegee Syphilis Study." American Journal of Preventive Medicine 12:4 (Jul./Aug. 1996), 242-46. |
| 1996 | Pace, Brian P. and Sullivan-Fowler, Micaela. "Proposed Compensation for Tuskegee Study Men." Journal of the American Medical Association 276:20 (27 Nov. 1996), 1692. |
| 1997 | Gamble, Vanessa. "Under the shadow of Tuskegee: African Americans and health care." American Journal of Public Health 87:11 (Nov. 1997), 1773-1778. |
| 1997 | Geiger, H. Jack. "Annotation: Racism resurgent – building a bridge to the 19th century." American Journal of Public Health 87:11 (Nov. 1997), 1765. |
| 1997 | Wolinsky, Howard. "Steps still being taken to undo damage of America ’s Nuremberg ." Annals of Internal Medicine 127:4 (15 Aug. 1997), 1-43. |
| 1997 | Ho, David and Wilfert, Catherine. "AIDS experts quit NEJM over editorial." Women’s Health Weekly (27 Oct. 1997), 2-3. |
| 1997 | Sargent, Joseph, dir. Miss Evers’ Boys. Videorecording. HBO Films, 1997. Based on the play by David Feldshuh. |
| 1998 | Gray, Fred. The Tuskegee Syphilis Study: The Real Story and Beyond. Montgomery, AL: Black Belt Press, 1998. [Note: Fred Gray is an attorney for some of the survivors.] |
| 1998 | Brawley, O.W. "The Study of Untreated Syphilis in the Negro Male." International Journal of Radiation Oncology and Biological Physics 40:1 (1 Jan. 1998), 5-8. |
| 1999 | Fairchild, Amy L. and Bayer, Ronald. "Uses and Abuses of Tuskegee." Science 284:5416 (7 May 1999), 919. |
| 1999 | Benedek, Thomas G. and Erlen, Jonathon. "The Scientific Environment of the Tuskegee Study of Syphilis, 1920-1960." Perspectives in Biology and Medicine 43:1 (Fall 1999), 1-30. |
| 2000 | Reverby, Susan, ed. Tuskegee’s Truths: Rethinking the Tuskegee Syphilis Study. Chapel Hill: University of North Carolina Press, 2000. |
| 2000 | White, Robert M. "Unraveling the Tuskegee Study of Untreated Syphilis." Archives of Internal Medicine 160:5 (2000), 585. |
While the PHS Syphilis Study at Tuskegee may not be directly responsible for changes to international codes of medical ethics, especially regarding informed consent, it is useful to see the progress made in this area. See the Resource entitled Codes of Medical and Human Experimentation Ethics, especially:
| 1947 | The Nuremberg Code: Provides standards to be followed by physicians experimenting on human subjects. For example, the person involved should have legal capacity to give consent, and the experiment should protect the experimental subject against even remote possibilities of injury, disability or death. |
| 1948 | Declaration of Geneva, Physician's Oath: (Revised in 1968, 1983, and 1994.) The physician pledges that the first commitment is to serve humanity, always putting the health of he patient first and will maintain the "utmost respect for human life." |
| 1953 | Wilson Memo: The subjects should be protected from harm as much as possible. If it looks like the experiment is doing more harm than good, the researcher must stop the experiment, no matter what stage it’s in. |
| 2000 | Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects: The focus of the Introduction is the primacy of patient health and well-being, with special attention to those "research populations are vulnerable and need special protection" as well as for "those who cannot give or refuse consent for themselves, for those who may be subject to giving consent under duress, for those who will not benefit personally from the research and for those for whom the research is combined with care." |
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